Plasmin-Mediated Proteolysis of Osteocalcin
نویسندگان
چکیده
منابع مشابه
Proteolysis of CCN1 by plasmin: functional implications.
Plasmin is shown to play a crucial role in many pathophysiologic processes primarily through its ability to degrade extracellular matrix (ECM) and/or mobilizing growth factors that are sequestered in the ECM. Cysteine-rich 61 (CCN1) is a matricellular protein of which expression is up-regulated in cancer and various vascular diseases. The present study was undertaken to investigate whether plas...
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Proteolytic enzymes are involved in generation of a number of endogenous angiogenesis inhibitors. Previously, we reported that angiostatin, a potent angiogenesis inhibitor, is a proteolytic fragment containing the first four kringle modules of plasminogen. In this report, we demonstrate that urokinase-activated plasmin can process plasminogen to release an angiogenesis inhibitor, K1-5 (protease...
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We have characterized the effects of plasmin on glycoprotein Ib (GpIb), a platelet membrane receptor for von Willebrand factor (vWF), and on glycocalicin, a fragment of the alpha chain of GpIb that contains the vWF-binding region. The addition of 4.5 X 10(-7) mol/L plasmin to washed platelets caused a time-dependent decrease in ristocetin-induced, vWF-dependent platelet agglutination. epsilon-A...
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Factor VIII coagulant protein (Vlll:C) functions as a critical cofactor with factor IXa, calcium ions. and phospholipid during the activation of factor X. In the course of this reaction, the activity of Vlll:C is first increased and then is destroyed by one or more serine proteases that are part of the coagulation sequence. In this study, we have investigated the influence of platelets on the i...
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ژورنال
عنوان ژورنال: Journal of Bone and Mineral Research
سال: 1997
ISSN: 0884-0431
DOI: 10.1359/jbmr.1997.12.7.1035